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SUMMARY:Stem cells to treat muscular dystrophies - Prof Jennifer Morgan (U
 CL)
DTSTART;VALUE=DATE-TIME:20231208T110000Z
DTEND;VALUE=DATE-TIME:20231208T120000Z
UID:https://talks.ox.ac.uk/talks/id/8503157e-38ce-406e-aab1-054aa0d3899f/
DESCRIPTION:Stem cell therapy was first suggested as a promising strategy 
 for treatment of muscular dystrophies such as Duchenne Muscular Dystrophy 
 (DMD) in the 1980s. The aim was to restore the missing protein\, dystrophi
 n\, in regenerated muscle fibres derived from donor cells. In addition to 
 muscle fibre formation\, reconstitution of the functional muscle stem cell
  pool by donor cells is vital for long-term treatment. Since then\, resear
 chers have tested the capacity of different types of stem cell to contribu
 te to skeletal muscle regeneration.  We have gained important insights int
 o the control of quiescence\, activation and differentiation of muscle ste
 m cells and the impact of a pathological muscle environment on the functio
 n of these cells.  But before stem cells could be considered for clinical 
 application\, there remain several hurdles to be overcome: producing suffi
 cient cells to treat skeletal muscles bodywide\, effective systemic delive
 ry of stem cells\, producing enough dystrophin in treated muscles to be of
  functional benefit and prevention of immune rejection of the cells or mus
 cle fibres of donor origin. \n\nBiography:\nJennifer Morgan is an emeritus
  professor in the Dubowitz Neuromuscular Centre\, University College Londo
 n Great Ormond Street Institute of Child Health. The main areas of her res
 earch are the identification of stem cells that contribute to skeletal mus
 cle regeneration\, and the genetic and functional manipulation of these ce
 ll populations to enhance muscle repair in skeletal muscle regenerative me
 dicine and in the treatment of muscular dystrophies.  She has also been in
 volved in pre-clinical work on the use of antisense oligonucleotides to re
 store dystrophin expression. \nSpeakers:\nProf Jennifer Morgan (UCL)
LOCATION:IMS-Tetsuya Nakamura Building (Seminar Room)\, Roosevelt Dr\, Hea
 dington OX3 7TY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/8503157e-38ce-406e-aab1-054aa0d3899f/
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DESCRIPTION:Talk:Stem cells to treat muscular dystrophies - Prof Jennifer 
 Morgan (UCL)
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