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SUMMARY:Receptor nanoclustering\, a new concept in chemokine complexity - 
 Professor Mario Mellado (National Center for Biotechnology/Spanish Researc
 h Council\, Spain)
DTSTART;VALUE=DATE-TIME:20201214T120000Z
DTEND;VALUE=DATE-TIME:20201214T130000Z
UID:https://talks.ox.ac.uk/talks/id/8902ccd6-541b-4bdc-b95e-6f98b998a62b/
DESCRIPTION:The initial observations describing chemokine receptors as a s
 imple system\, with a ligand that binds a unique receptor and activates a 
 Gi protein to trigger calcium flux and cell migration\, has evolved to a h
 ighly complex signaling machinery that facilitates cell adaptation to the 
 environment. The use of new technical approaches that allow precise analys
 is of protein-protein interactions in living cells is revealing an unantic
 ipated level of complexity among chemokines and chemokine receptors at the
  cell surface\, and supports previous data on allosteric interactions. Thi
 s complexity reflects a highly regulated system that allows the precise ce
 ll allocation to trigger the optimal response. Knowledge of the dynamic in
 teractions of the ligands and receptors\, as well as their interplay with 
 other proteins co-expressed by the cell\, with lipids that form the cell m
 embrane\, with the cellular cytoskeleton\, and with downstream signaling m
 achinery will be crucial to define the context-specific signaling triggere
 d by chemokines and to determine how these inflammatory mediators modulate
  cell responses. Using a natural mutant of CXCR4\, responsible of the Wart
 s\, Hypogammaglobulinemia\, Infections and Myelokathexis (WHIM) syndrome\,
  a rare\, autosomal dominant\, primary immunodeficiency disorder we will s
 ee how the complexity can affect receptor function and explain the phenoty
 pe of this rare immunodeficiency.\nSpeakers:\nProfessor Mario Mellado (Nat
 ional Center for Biotechnology/Spanish Research Council\, Spain)
LOCATION:Kennedy Institute of Rheumatology (This seminar will be held usin
 g Zoom. Please register here:  https://zoom.us/meeting/register/tJ0pf-6sqj
 wvGtEByUba8IdAPBC-mUo4MeSb )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/8902ccd6-541b-4bdc-b95e-6f98b998a62b/
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DESCRIPTION:Talk:Receptor nanoclustering\, a new concept in chemokine comp
 lexity - Professor Mario Mellado (National Center for Biotechnology/Spanis
 h Research Council\, Spain)
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