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SUMMARY:A break in mitochondrial endosymbiosis as a basis for inflammatory
  diseases - Professor Luke O'Neill (Trinity College Dublin)
DTSTART;VALUE=DATE-TIME:20240502T120000
DTEND;VALUE=DATE-TIME:20240502T130000
UID:https://talks.ox.ac.uk/talks/id/9366de9d-f669-4876-9237-72572dd64421/
DESCRIPTION:The endosymbiotic origin of mitochondria means that within our
  cells we host hundreds of organelles that retain many aspects of their ba
 cterial origin which must be tolerated. Consequently\, the release of mito
 chondrial factors into the cytosol can trigger cell death\, innate immunit
 y and inflammation. A range of findings in immunometabolism have revealed 
 how mitochondria are an important source of factors that promote immunity 
 and inflammation. These include mitochondrial nucleic acids that can be se
 nsed by innate sensors such as cGAS and MDA-5\, metabolites such as succin
 ate\, fumarate and itaconate\, that have a range of effects\, with itacona
 te in particular being anti-inflammatory. Recent work from my lab has unco
 vered a role of fumarate hydratase in driving the release of mitochondrial
  double-stranded RNA\, and a role of reactive oxygen species made by Compl
 ex III in the electron transport chain as being key for IL10 induction. Si
 nce mitochondrial change appears critical for inflammation\, it could be t
 hat environmental factors\, including obesity\, pathogens or toxins\, migh
 t promote a breakdown in endosymbiosis. This could be part of why the inci
 dence of autoimmune disease has increased substantially over the past 50 y
 ears or so.\nSpeakers:\nProfessor Luke O'Neill (Trinity College Dublin)
LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H
 eadington OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/9366de9d-f669-4876-9237-72572dd64421/
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DESCRIPTION:Talk:A break in mitochondrial endosymbiosis as a basis for inf
 lammatory diseases - Professor Luke O'Neill (Trinity College Dublin)
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