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SUMMARY:Neuroimmunometabolism - by Dr Ana Domingos\, University of Oxford 
 - Professor Ana Domingos (University of Oxford\, DPAG)
DTSTART;VALUE=DATE-TIME:20210311T183000Z
DTEND;VALUE=DATE-TIME:20210311T193000Z
UID:https://talks.ox.ac.uk/talks/id/97069af0-d95e-421b-9e3d-5cfd2917512b/
DESCRIPTION:For joining details please see the Society's FB events page: h
 ttps://fb.me/e/15v36zbce\n\nThe Domingos laboratory researches neuroimmune
  mechanisms underlying obesity. They discovered neuro-adipose junctions\, 
 between white adipocytes and sympathetic neurons\, that are necessary and 
 sufficient for fat mass reduction via norepinephrine (NE) signalling. More
 over\, they discovered Sympathetic neuron-\nAssociated Macrophages (SAMs) 
 that import and metabolize NE. Abrogation of SAM function promotes long-te
 rm amelioration of obesity independently of food intake. These findings in
 spired the development of a new class of anti-obesity compounds named symp
 athofacilitators\, which do not enter the brain\, nor have the typical car
 diovascular side effects of centrally acting sympathomimetic drugs. Sympat
 hofacilitator drugs act as an energy sink by coupling thermogenesis to act
 ive heat dissipation.\nAna Domingos is a member of the advisory board of C
 ell Metabolism and is a member of the board of reviewing editors at eLife.
  Her lab has been funded by HHMI\, Wellcome Trust\, ERC\, HFSP\, EMBO amon
 g other.\nSpeakers:\nProfessor Ana Domingos (University of Oxford\, DPAG)
LOCATION:virtual livestream
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/97069af0-d95e-421b-9e3d-5cfd2917512b/
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DESCRIPTION:Talk:Neuroimmunometabolism - by Dr Ana Domingos\, University o
 f Oxford - Professor Ana Domingos (University of Oxford\, DPAG)
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