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SUMMARY:Exploring the dynamics of DNA methylation and interaction with gen
 otype in response to inflammatory stimuli - Benjamin Fairfax (Department o
 f Oncology\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20180118T110000Z
DTEND;VALUE=DATE-TIME:20180118T120000Z
UID:https://talks.ox.ac.uk/talks/id/9b0c5c7f-c510-48ec-a186-20cac641c021/
DESCRIPTION:Chronic inflammation is implicated in the pathogenesis of the 
 majority of common diseases including cancer. Understanding the molecular 
 determinants of the inflammatory response is therefore of high importance 
 to human health. DNA methylation at cytosine:guanine dinucleotides (CpGs) 
 is a key epigenetic mark that elicits pronounced transcriptional consequen
 ces. How DNA methylation changes over the inflammatory response\, and the 
 influence of genetic variation on this is relatively unexplored. \n\nI wil
 l present novel data from a project to explore variation in monocyte DNA m
 ethylation during exposure to divergent inflammatory stimuli with referenc
 e to genotype. I will also describe an ongoing project whereby these findi
 ngs are being translated to cancer in an effort to dissect the epigenetic 
 impact of malignancy on circulating immune subsets.\n\nSpeakers:\nBenjamin
  Fairfax (Department of Oncology\, University of Oxford)
LOCATION:NDM Building (Basement seminar room\, TDI)\, Headington OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/9b0c5c7f-c510-48ec-a186-20cac641c021/
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DESCRIPTION:Talk:Exploring the dynamics of DNA methylation and interaction
  with genotype in response to inflammatory stimuli - Benjamin Fairfax (Dep
 artment of Oncology\, University of Oxford)
TRIGGER:-PT1H
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