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SUMMARY:Increasing memory potential: How asymmetric cell division modulati
 on impacts T cell fate - Dr Mariana Borsa (Swiss Federal Institute of Tech
 nology in Zurich (ETH Zürich))
DTSTART;VALUE=DATE-TIME:20180122T120000Z
DTEND;VALUE=DATE-TIME:20180122T130000Z
UID:https://talks.ox.ac.uk/talks/id/a180d65f-b2c2-4132-812f-dbef2414e9a5/
DESCRIPTION:Asymmetric cell division (ACD) is a conserved mechanism to est
 ablish differentiation\, resulting in two daughter cells with differential
  potential fates. We compared the extent of ACD upon activation of differe
 nt subsets of CD8+ T cells. Our results suggest that "stem" cells endowed 
 with the ability to undergo clonal (re)expansion show higher ACD rates in 
 comparison to cells that are unable to form a memory reservoir. Furthermor
 e\, we found that mTOR inhibition is able to increase ACD rates and that t
 his reflects in daughter cells that\, when transferred to new hosts and su
 bmitted to viral rechallenge\, show better re-expansion and virus protecti
 on capacity.\n----\nI graduated in Biology in 2010 at the Federal Universi
 ty of Santa Catarina (UFSC) in Brazil. I was awarded a CNPq 'scientific in
 itiation' fellowship from 2008 to 2010 and in that period I studied the im
 mune system of Crustacea and developed monoclonal antibodies for immunodet
 ection of shrimp viruses (Borsa et al.\, 2011\; Seibert et al.\, 2010). I 
 completed my Masters degree in Biotechnology and Biosciences also at UFSC 
 in 2012. I was awarded a CAPES fellowship for the period of my Master stud
 ies about Unfolded Protein Response (UPR) activation by HIV infection (Bor
 sa et al.\, 2015). I then worked as a Biology high school teacher in Brazi
 l until I joined the lab of Annette Oxenius at ETHZ in 2014. During my PhD
  I have been working with asymmetric cell division in CD8 T lymphocytes an
 d trying to understand how this mechanism impacts T cell fate and can be m
 odulated to provide better memory potential and protection against viral i
 nfections.\nSpeakers:\nDr Mariana Borsa (Swiss Federal Institute of Techno
 logy in Zurich (ETH Zürich))
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre
 )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/a180d65f-b2c2-4132-812f-dbef2414e9a5/
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DESCRIPTION:Talk:Increasing memory potential: How asymmetric cell division
  modulation impacts T cell fate - Dr Mariana Borsa (Swiss Federal Institut
 e of Technology in Zurich (ETH Zürich))
TRIGGER:-PT1H
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