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SUMMARY:Genetics\, Viruses\, and B cells: the Cause of Multiple Sclerosis 
 - Professor David Hafler (Yale School of Medicine)
DTSTART;VALUE=DATE-TIME:20260219T120000Z
DTEND;VALUE=DATE-TIME:20260219T130000Z
UID:https://talks.ox.ac.uk/talks/id/a8c750a6-a421-4b25-a460-235bae2514a3/
DESCRIPTION:A pipeline was developed to quantify EBV DNA from whole-genome
  sequencing data in a cohort of over half million subjects identifying 39 
 susceptibility risk loci. A significant overlap with genetic variants asso
 ciated with MS risk was observed p<10-12. These data suggest that EBV-infe
 cted B cells may constituted a critical hub that modulates T cell response
 s while activating MS gene linked susceptibility pathways within B cells. 
 Finally\, B cell depletion is almost totally effective in stopping autoimm
 une MS. Thus\, we define a genetic and cellular framework linking B cells 
 to the initiation of MS and support a causal role of EBV activity on MS ri
 sk.\nSpeakers:\nProfessor David Hafler (Yale School of Medicine)
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/a8c750a6-a421-4b25-a460-235bae2514a3/
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DESCRIPTION:Talk:Genetics\, Viruses\, and B cells: the Cause of Multiple S
 clerosis - Professor David Hafler (Yale School of Medicine)
TRIGGER:-PT1H
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