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SUMMARY:The regulation of neural stem cell quiescence by a physical niche 
 - Professor Isabel Farinas (University of Valencia)
DTSTART;VALUE=DATE-TIME:20250924T120000
DTEND;VALUE=DATE-TIME:20250924T130000
UID:https://talks.ox.ac.uk/talks/id/aab09393-8301-4710-afcf-cdb8f8d09189/
DESCRIPTION:1Centro de Investigación Biomédica en Red sobre Enfermedades
  Neurodegenerativas (CIBERNED)\, 2Departamento de Biología Celular\, Biol
 ogía Funcional y Antropología Física\, 3Instituto de Biotecnología y B
 iomedicina (BioTecMed)\, Universidad de Valencia\, 46100 Burjassot\, Spain
 .\n \nNew neurons for highly plastic olfactory circuits are produced in th
 e subependymal zone (SEZ) of the adult mammalian brain. Neural stem cells 
 (NSCs) in this niche have access to a wide range of regulatory signals tha
 t promote continuous lifelong neurogenesis while preserving the stem cell 
 pool. NSCs derive from radial glial cells\, which are the primary embryoni
 c progenitor type in the vertebrate brain\, and inherit from them part of 
 their transcriptional program\, a bipolar elongated morphology with apico-
 basal polarity that allows for unique interactions with neighboring cell t
 ypes\, and markers associated with the astrocytic lineage. In contrast to 
 their fetal counterparts\, most adult NSCs remain in a quiescent state und
 er physiological conditions. It is now widely accepted that NSCs in the SE
 Z exist in at least three states: quiescent (q)\, quiescent but prone to a
 ctivation or primed (p)\, and activated (a)\, each characterized by unique
  and distinct transcriptional profiles. Transitions between states likely 
 involve significant changes in cellular physiology tightly regulated by bo
 th intrinsic and extrinsic factors. We have found that entry into quiescen
 ce is associated with the deposition of specific extracellular matrix comp
 onents and that adhesion to the matrix produced in response to pro-quiesce
 nt signals alone can induced a quiescent-like state in proliferative NSCs.
  This entry into quiescence depends on the RhoA-associated kinase ROCK and
  yes-associated protein (YAP) transcriptional activity. YAP/TAZ deletion i
 n NSCs leads to the loss of ECM deposition and quiescence in vivo suggesti
 ng that they regulate the physical niche and a quiescence-associated gene 
 expression program in response to mechanical cues. \nSpeakers:\nProfessor 
 Isabel Farinas (University of Valencia)
LOCATION:Sherrington Library (Sherrington Building)\, off Parks Road OX1 3
 PT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/aab09393-8301-4710-afcf-cdb8f8d09189/
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DESCRIPTION:Talk:The regulation of neural stem cell quiescence by a physic
 al niche - Professor Isabel Farinas (University of Valencia)
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