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SUMMARY:Type-1 interferon response in metabolic inflammation and cellular 
 bioenergetics - Dr Fawaz Alzaid (Paris’ Cordeliers Research Centre\, Fra
 nce)
DTSTART;VALUE=DATE-TIME:20191104T120000Z
DTEND;VALUE=DATE-TIME:20191104T130000Z
UID:https://talks.ox.ac.uk/talks/id/afe68ebe-fa61-4ef8-950b-42dded21c1b5/
DESCRIPTION:Metabolic inflammation in type-2 diabetes (T2D) is initiated b
 y type-1 interferon signalling\, through its transcriptional mediator IRF5
 . Whilst studies in auto-immunity link pro-inflammatory polarisation to in
 creased glycolysis\, this phenomenon remains unexplored in T2D or in the c
 ontext of IRF5-dependent inflammation. We hypothesise that macrophage bioe
 nergetic adaptation in T2D is distinct\, due to the distinct nature of ins
 ult and systemic abundance of substrates. IRF5 may play a key role in adap
 ting cellular bioenergetics to initiate\, amplify and sustain inflammation
 . To address these hypotheses\, we analysed public and in-house sequencing
  datasets and carried out mechanistic in vivo and ex vivo analyses.\nSpeak
 ers:\nDr Fawaz Alzaid (Paris’ Cordeliers Research Centre\, France)
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre
 )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/afe68ebe-fa61-4ef8-950b-42dded21c1b5/
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DESCRIPTION:Talk:Type-1 interferon response in metabolic inflammation and 
 cellular bioenergetics - Dr Fawaz Alzaid (Paris’ Cordeliers Research Cen
 tre\, France)
TRIGGER:-PT1H
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