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SUMMARY:Orexin/hypocretin knockout impairs mouse visual perception\, proce
 ssing and plasticity\, and disrupts development of the cortical subplate -
  Dr Cornelia Schöne (University of Göttingen)
DTSTART;VALUE=DATE-TIME:20260226T160000Z
DTEND;VALUE=DATE-TIME:20260226T170000Z
UID:https://talks.ox.ac.uk/talks/id/b43f873b-953d-4146-8605-dcc3cadb8733/
DESCRIPTION:Lateral hypothalamic orexin/hypocretin circuits are required f
 or stable consciousness: loss of orexin signals causes narcolepsy in human
 s\, dogs and mice. While orexins activate deep cortical layers in mouse pr
 imary visual cortex (V1)\, their role for vision remains underexplored. On
  a behavioral/perceptual level\, orexin knockout (KO) mice had normal visu
 al acuity\, but worse orientation discrimination\, needing a larger angle 
 difference to discriminate square wave patterns. Using the oddball paradig
 m\, in which a stimulus is presented frequently (redundant context) or rar
 ely (oddball context)\, we provide electrophysiological evidence suggestin
 g disrupted V1 processing of visual signals in anaesthetized orexin KO mic
 e. This includes delayed peaks of visually evoked potentials (VEP) and dis
 ruption of context dependent modulation of VEP waveform and power spectra.
  The cause for these impairments might be developmental in nature: Orexin 
 KO mice showed extended survival of cortical subplate cells and altered de
 velopment of layer 6 during early postnatal development. As orexins were p
 reviously shown to specifically activate deep cortical layers\, which driv
 e high gamma brain states favorable for plasticity\, but that are lost in 
 orexin KO mice\, here we further tested whether orexin KO would impair pla
 sticity during development. Indeed\, orexin KO disrupted monocular depriva
 tion induced ocular dominance plasticity specifically during the late crit
 ical period for visual circuit development\, suggesting disruption of expe
 rience-dependent plasticity of V1 circuits during this paradigm. Together 
 our data show that loss of orexin peptides affects development of visual c
 ircuits\, and causes deficits in visual perception\, processing and plasti
 city.\nSpeakers:\nDr Cornelia Schöne (University of Göttingen)
LOCATION:Sherrington Building (Florence Buchanan Lecture Theatre)\, off Pa
 rks Road OX1 3PT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/b43f873b-953d-4146-8605-dcc3cadb8733/
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DESCRIPTION:Talk:Orexin/hypocretin knockout impairs mouse visual perceptio
 n\, processing and plasticity\, and disrupts development of the cortical s
 ubplate - Dr Cornelia Schöne (University of Göttingen)
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