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PRODID:talks.ox.ac.uk
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SUMMARY:Temporally regulated amino acid uptake through SLC7A5 is required 
 for CD4+ effector T cell differentiation - Dr Linda Sinclair (University o
 f Dundee)
DTSTART;VALUE=DATE-TIME:20181203T120000Z
DTEND;VALUE=DATE-TIME:20181203T130000Z
UID:https://talks.ox.ac.uk/talks/id/cee0414d-6581-4022-854c-00cb57f09cfb/
DESCRIPTION:T follicular helper cells (TFH) are critical cells for germina
 l center (GC) formation and for the production of high affinity\, isotype-
 switched antibody responses. Using a novel single cell assay for System L 
 amino acid transport\, we show that the in vivo differentiation of TFH is 
 accompanied by sustained regulation of System L amino acid transport capac
 ity. The System L transporter\, SLC7A5\, has a key role in activated T cel
 ls to transport the essential amino acid methionine. Methionine is require
 d for de novo protein synthesis and is also the biosynthetic precursor for
  S-adenosylmethionine (SAM)\, the main methyl donor used in the DNA\, RNA 
 and histone modifications that regulate cellular transcriptional programs.
  In particular\, regulated methionine delivery to the cell interior is rat
 e limiting for RNA methylation and for coordinating epigenetic histone mod
 ifications in immune activated T cells. SLC7A5 expression is thus a critic
 al metabolic checkpoint linking nutrient supply to key processes required 
 for effector T cell differentiation.\n----\nLinda was born in Lund\, Swede
 n and had a varied international primary and secondary schooling\, finally
  coming to rest in Scotland\; she received her undergraduate degree in Imm
 unology from Edinburgh\, followed by her PhD from Dundee. Since then she h
 as continued working with Doreen Cantrell to advance understanding on how 
 nutrient availability impacts upon the immune system\, specifically on the
  activation\, differentiation and function of T lymphocytes. – demonstra
 ting a novel role for the metabolic sensor mTOR in regulating lymphocyte h
 oming (Nat Imm 2008) – demonstrating that regulated expression of SLC7A5
  (an amino acid transporter) is required to co-ordinate the metabolic repr
 ogramming of cytotoxic T cells upon antigen stimulation\, both to sustain 
 mTOR signalling and c-MYC expression (Nat Imm 2013\, EMBO 2015)\nSpeakers:
 \nDr Linda Sinclair (University of Dundee)
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Theatre)\, Head
 ington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/cee0414d-6581-4022-854c-00cb57f09cfb/
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DESCRIPTION:Talk:Temporally regulated amino acid uptake through SLC7A5 is 
 required for CD4+ effector T cell differentiation - Dr Linda Sinclair (Uni
 versity of Dundee)
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