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SUMMARY:Biological roles of hematopoietic niches in the origination and de
 velopment of leukemia - Professor Dengli Hong (Shanghai Jiao Tong Universi
 ty School of Medicine)
DTSTART;VALUE=DATE-TIME:20230803T120000
DTEND;VALUE=DATE-TIME:20230803T130000
UID:https://talks.ox.ac.uk/talks/id/cf365189-de83-48ef-9aff-c58d8c489702/
DESCRIPTION:My group studies biological roles of hematopoietic niches in t
 he origination and development of leukaemia\, making effort to address two
  issues of pathogenesis and therapeutics of the disease. First\, how devel
 opmental tissue microenvironments provide genome protection for hematopoie
 tic \n tem and progenitor cells (HSPCs) and how the native lack or patholo
 gical loss of protection results in NDA damage and genome instability in H
 SPCs when encountering endogenous\, e.g. metabolic\, or exogenous genotoxi
 c agents and leukaemia initiation. Second\, how leukaemic microenvironment
 s provide protective niches for leukaemic propagating cells in evading the
 rapy including chemotherapy and immunotherapy. The aims of these studies a
 re to identify and characterise the niche cells and molecules that are inv
 olved in leukaemia initiation and development and that can be targeted for
  disease prevention and future therapies. We have recently identified a le
 ukaemogenic niche in the foetal liver and several therapyinduced niches in
  the leukaemic bone marrow. In the seminar talk I will share these interes
 ting findings. \nSpeakers:\nProfessor Dengli Hong (Shanghai Jiao Tong Univ
 ersity School of Medicine)
LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H
 eadington OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/cf365189-de83-48ef-9aff-c58d8c489702/
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DESCRIPTION:Talk:Biological roles of hematopoietic niches in the originati
 on and development of leukemia - Professor Dengli Hong (Shanghai Jiao Tong
  University School of Medicine)
TRIGGER:-PT1H
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