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SUMMARY:Role and Regulation of DNA modifications  - Professor Heinrich Leo
 nhardt (Ludwig Maximilian University Munich)
DTSTART;VALUE=DATE-TIME:20260112T130000Z
DTEND;VALUE=DATE-TIME:20260112T140000Z
UID:https://talks.ox.ac.uk/talks/id/cfed14e4-2831-46f6-9021-dfc015666c07/
DESCRIPTION:Several decades after the first observation of DNA modificatio
 ns in mammals\, we still do not know why some DNA bases are modified and w
 hether it really matters to begin with. Although there are only three DNA 
 methyltransferases (DNMTs) and three DNA oxygenases (TETs)\, an infinite n
 umber of DNA modification patterns can be observed throughout development 
 and disease. Over the past decades\, several functional links with other e
 pigenetic pathways and cellular metabolism have been described. In this ta
 lk\, I will focus on the surprising and opposing roles of TET\, UHRF1 and 
 DPPA3 in  the regulation of DNA modifications and pluripotency. I will pre
 sent data on the pivotal role of ubiquitination in regulating DNA modifica
 tions\, as well as new regulatory mechanisms.\n\n\nSpeakers:\nProfessor He
 inrich Leonhardt (Ludwig Maximilian University Munich)
LOCATION:Dorothy Crowfoot Hodgkin Building (Seminar Room 2 (Room 20-138))\
 , off South Parks Road OX1 3QU
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/cfed14e4-2831-46f6-9021-dfc015666c07/
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DESCRIPTION:Talk:Role and Regulation of DNA modifications  - Professor Hei
 nrich Leonhardt (Ludwig Maximilian University Munich)
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