BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:Peptide-empty MHC class I molecules on the cell surface and in bio
 technology - Professor Sebastian Springer (School of Science\, Constructor
  University Bremen)
DTSTART;VALUE=DATE-TIME:20250821T130000
DTEND;VALUE=DATE-TIME:20250821T140000
UID:https://talks.ox.ac.uk/talks/id/e14de387-2981-4a5c-ac67-7b1b04bce924/
DESCRIPTION:Our research is in the area of immunology\, molecular cell bio
 logy\, and biochemistry\, specifically on the intracellular transport of m
 embrane proteins of the immune system\, and its regulation. Our favourite 
 model system is major histocompatibility complex (MHC) class I molecules\,
  which are present on all nucleated cells. They play a central role in the
  mammalian immune defence against viruses\, intracellular bacteria\, and c
 ancer\, since they carry fragments of many intracellular proteins to the s
 urface of the cell\, where they can be surveyed by cytotoxic T lymphocytes
  (CTL). If the CTL find that unusual proteins (for example\, non-self) are
  produced in the cell\, they induce it to undergo apoptosis. This way\, th
 e production sites of viruses are eliminated.\nA second project area conce
 rns the introduction of soluble substances\, for example peptides or secon
 d messengers\, into cells\, either to manipulate their behaviour or to mak
 e measurements. We work with biophysicists who design micrometer-sized cap
 sules that can be opened inside the cells. This system is also used to stu
 dy MHC class I molecules. Our main methods are laser confocal fluorescence
  microscopy\, cell biological protein transport experiments (pulse chases)
 \, biochemical in vitro assays of intracellular transport processes\, and 
 biophysical assays with purified proteins.\nSpeakers:\nProfessor Sebastian
  Springer (School of Science\, Constructor University Bremen)
LOCATION:Seminar Room\, NDM Research Building\, Old Road Campus\, Headingt
 on\, OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/e14de387-2981-4a5c-ac67-7b1b04bce924/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Peptide-empty MHC class I molecules on the cell surface a
 nd in biotechnology - Professor Sebastian Springer (School of Science\, Co
 nstructor University Bremen)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR