BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:The double burden of diabetes and global infection  - Susanna Duna
 chie (University of Oxford)
DTSTART;VALUE=DATE-TIME:20191120T143000Z
DTEND;VALUE=DATE-TIME:20191120T153000Z
UID:https://talks.ox.ac.uk/talks/id/e2b2d143-f3e6-4612-8023-bd25f5c59958/
DESCRIPTION:77% of people with diabetes mellitus now live in low and middl
 e-income countries (LMIC)\, and the incidence of diabetes is accelerating 
 in poorer communities. The majority of people with diabetes are thought to
  have Type 2 diabetes mellitus (T2DM) although further research on diabete
 s subtypes in LMIC is needed. Diabetes increases susceptibility to infecti
 on and / or worsens outcomes for major global infections such as tuberculo
 sis (TB)\, dengue\, influenza and Gram-negative sepsis including Salmonell
 a species and the neglected tropical disease melioidosis. Melioidosis is c
 aused by the soil bacterium Burkholderia pseudomallei\, has a 40% hospital
 ised case fatality rate in LMIC\, and an estimated 89\,000 global death to
 ll. People with diabetes have a twelve-fold increased risk of melioidosis 
 compared to non-diabetics\, and up to two-thirds of melioidosis patients h
 ave T2DM. There is a large overlap between populations at risk of diabetes
  and those at risk of melioidosis\, resulting in an estimated 280 million 
 people with diabetes now living in melioidosis-endemic countries across th
 e world. In addition\, people with diabetes bear a disproportionate burden
  of drug-resistant infections from bacteria with antimicrobial resistance 
 (AMR).\n\nThis talk will give an overview of what is known about the epide
 miology of diabetes and infection\, and discuss potential mechanisms for t
 he increased risk of infection\, and in particular for the exquisite susce
 ptibility of people with diabetes to melioidosis. International treatment 
 guidelines for T2DM are based on research conducted in high-income countri
 es focussed on preventing adverse cardiovascular outcomes and early death.
  There is a lack of evidence on which to base treatment guidelines for peo
 ple living in LMIC\, where there is an increased burden of infectious dise
 ases. The literature to date on the impact of treatment on infection risk 
 and outcomes will be discussed. Finally\, the role of vaccination of peopl
 e with diabetes will be discussed. It is noted that a public health vaccin
 e for melioidosis would be targeted at people with diabetes in the first i
 nstance\, as this group represents a well-defined and accessible populatio
 n for evaluation of a melioidosis vaccine.\nSpeakers:\nSusanna Dunachie (U
 niversity of Oxford)
LOCATION:75 George Street (Hayes House) (Seminar Room\, 1st Floor\, Hayes 
 House. Lift and stair access)\, 75 George Street OX1 2BQ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/e2b2d143-f3e6-4612-8023-bd25f5c59958/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The double burden of diabetes and global infection  - Sus
 anna Dunachie (University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR