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SUMMARY:Unconventional lipid-antigen recognition by group 1 CD1 restricted
  T cells - Dr Adam Shahine (University of Monash)
DTSTART;VALUE=DATE-TIME:20260202T130000Z
DTEND;VALUE=DATE-TIME:20260202T140000Z
UID:https://talks.ox.ac.uk/talks/id/e35a6a3a-27b6-4a43-b4a5-26fda1d0065b/
DESCRIPTION:TItle: Unconventional lipid-antigen recognition by group 1 CD1
  restricted T cells \n\nBrief description: Beyond peptides\, lipid antigen
 s are presented to T cells by the CD1 family of antigen-presenting molecul
 es\, providing a parallel system of immune surveillance that has been less
  explored than peptide-MHC recognition. While CD1d-restricted natural kill
 er T (NKT) cells and their T cell receptor (TCR) recognition mechanisms ar
 e well characterised\, far less is known about how the group 1 CD1 molecul
 es (CD1a\, CD1b\, and CD1c) present lipids and engage diverse TCR repertoi
 res\, leaving lipid-reactive immunity incompletely understood. Early model
 s of lipid antigen presentation assumed close analogy to peptide-MHC recog
 nition\, with antigens displayed in an upright\, end-to-end orientation fo
 r TCR engagement. However\, structural studies demonstrate that group 1 CD
 1 molecules use broader and more flexible antigen display strategies to ac
 commodate a wide range of self- and foreign- lipid antigens. Notably\, we 
 identified a non-canonical CD1c mechanism in which bulky lipid antigens ar
 e displayed in a sideways orientation\, challenging long-standing assumpti
 ons about antigen presentation and immune surveillance. Using X-ray crysta
 llography\, structural computation\, and more recently cryo- electron micr
 oscopy\, we have defined multiple modes of TCR engagement across CD1a\, CD
 1b\, and CD1c\, including lipid co-recognition and lipid-independent docki
 ng\, and uncovered public and gene-biased TCR docking mechanisms. Together
 \, these findings revise classical models of lipid antigen presentation an
 d raise fundamental questions about how distinct display modes shape T cel
 l specificity and function in immunity.\n\nShort bio: Dr Adam Shahine is a
  mid-career researcher and currently an NHMRC Emerging Leadership Fellow w
 ithin the Department of Biochemistry and Molecular Biology at the Monash B
 iomedicine Discovery Institute (BDI)\, Melbourne\, Australia. He obtained 
 his PhD in Biochemistry in 2016 and has since undergone postdoctoral train
 ing both in Monash (Aus) and Cardiff University (UK). In 2023\, he was app
 ointed as a BDI group leader\, where his group focuses on the molecular ch
 aracterisation of lipid antigen presentation and processing by group 1 CD1
  molecules to T cells. His research predominantly focuses on establishing 
 the molecular determinants of lipid antigen presentation by each CD1 membe
 r\, the models of unconventional lipid mediated T cell receptor recognitio
 n\, and in the context of disease\, the role of lipid presentation in M. t
 uberculosis infection and immune dysregulation in autoimmunity.\n\nSpeaker
 s:\nDr Adam Shahine (University of Monash)
LOCATION:This webinar is online\, registration is required
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/e35a6a3a-27b6-4a43-b4a5-26fda1d0065b/
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DESCRIPTION:Talk:Unconventional lipid-antigen recognition by group 1 CD1 r
 estricted T cells - Dr Adam Shahine (University of Monash)
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