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SUMMARY:Nucleic Acid Sensing by Innate Immune Receptors - Prof Jan Rehwink
 el ((Radcliffe Department of Medicine) University of Oxford)
DTSTART;VALUE=DATE-TIME:20180716T120000
DTEND;VALUE=DATE-TIME:20180716T130000
UID:https://talks.ox.ac.uk/talks/id/ef79f62c-257f-48ef-9e75-820c2de0b49f/
DESCRIPTION:The innate immune response is critical for successful host def
 ence against virus infection. Cell-intrinsic mechanisms detect virus prese
 nce and restrict virus replication. Nucleic acids are often a molecular si
 gnature of virus infection and are recognised by innate receptors includin
 g toll-like receptors\, RIG-I-like receptors and cytosolic DNA sensors. Th
 ese receptors signal for the induction of innate response genes such as th
 ose encoding type I interferons. These in turn induce the expression of re
 striction factors\, host proteins that limit virus replication.\nOur work 
 focuses on cytosolic nucleic acid sensors\, in particular RIG-I\, MDA5 and
  cGAS. We are also studying the restriction factor SAMHD1. We are using in
  vitro and in vivo models of virus infection (including influenza A virus\
 , retroviruses and varicella-zoster virus) and are interested in Aicardi-G
 outières syndrome\, a rare genetic disease linked to chronic anti-viral i
 nnate immune responses. In this presentation\, I will discuss our recent w
 ork on cGAS and other nucleic acid sensors.\nSpeakers:\nProf Jan Rehwinkel
  ((Radcliffe Department of Medicine) University of Oxford)
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre
 )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/ef79f62c-257f-48ef-9e75-820c2de0b49f/
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DESCRIPTION:Talk:Nucleic Acid Sensing by Innate Immune Receptors - Prof Ja
 n Rehwinkel ((Radcliffe Department of Medicine) University of Oxford)
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