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SUMMARY:T cell immunity begins with TCR allosteric activation - Professor 
 Oreste Acuto (University of Oxford )
DTSTART;VALUE=DATE-TIME:20191209T120000Z
DTEND;VALUE=DATE-TIME:20191209T130000Z
UID:https://talks.ox.ac.uk/talks/id/f23edde3-2d7a-49a0-859f-0183a0ffcfbc/
DESCRIPTION:T cell-dependent immunity commences with T-cell antigen recept
 or (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition\, sign
 alling modalities and convoluted quaternary structure\, diverging consider
 ably from “classic”\, evolutionary ancient membrane receptors of simpl
 er molecular design and univocal relationship to ligands. TCR-CD3 recognis
 es with exceptional sensorial and discriminatory ability antigens of varyi
 ng structure\, quantity and detection context. Given such a complexity\, i
 t is perhaps unsurprising that controversy exists on how TCR-CD3 works. I 
 will report new data suggesting an allosteric mechanism by which TCR-CD3 t
 ransmits signals across the plasma membrane that should improve our unders
 tanding of how T cell activation begins.\nSpeakers:\nProfessor Oreste Acut
 o (University of Oxford )
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre
 )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f23edde3-2d7a-49a0-859f-0183a0ffcfbc/
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DESCRIPTION:Talk:T cell immunity begins with TCR allosteric activation - P
 rofessor Oreste Acuto (University of Oxford )
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