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SUMMARY:Mapping the rules of glioblastoma using single cell and spatial ge
 nomics - Dr Omer Bayraktar (Wellcome Sanger Institute\, Cambridge )
DTSTART;VALUE=DATE-TIME:20260309T120000Z
DTEND;VALUE=DATE-TIME:20260309T130000Z
UID:https://talks.ox.ac.uk/talks/id/f5f6646f-fde9-4307-a028-0cf698feddeb/
DESCRIPTION:Cancer cells display heterogeneous and dynamic states in gliob
 lastoma\, but how these malignant states arise and whether they follow a t
 ractable cellular trajectory across tumours is poorly understood. Here\, w
 e generate a deep single cell and spatial multi-region atlas of glioblasto
 ma that integrates transcriptomic\, epigenomic and genomic analysis to com
 prehensively characterise their tumour heterogeneity. We describe spatiall
 y-patterned transitions of malignant cells from dev-like towards glial inj
 ury response- and hypoxia-defined states during tumour expansion. This mal
 ignant cell trajectory dominates glioblastoma\, manifesting across tumours
  and genetically distinct subclonal lineages that are finely spatially int
 ermixed within tumours. Moreover\, this trajectory unfolds across speciali
 sed myeloid signalling environments that mirror the spatial compartmentali
 zation of malignant cells. Our findings define a stereotyped trajectory of
  cancer cells in glioblastoma and unify glioblastoma tumour heterogeneity 
 into a tractable cellular and tissue framework.\nSpeakers:\nDr Omer Bayrak
 tar (Wellcome Sanger Institute\, Cambridge )
LOCATION:Old Road Campus Research Building (Oncology Education Hub)\, Head
 ington OX3 7DQ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f5f6646f-fde9-4307-a028-0cf698feddeb/
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DESCRIPTION:Talk:Mapping the rules of glioblastoma using single cell and s
 patial genomics - Dr Omer Bayraktar (Wellcome Sanger Institute\, Cambridge
  )
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