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SUMMARY:Breast and ovarian cancer susceptibility: what have we learned fro
 m large international consortia? - Dr Antonis Antoniou (Centre for Cancer 
 Genetic Epidemiology\, Cambridge)
DTSTART;VALUE=DATE-TIME:20171109T110000Z
DTEND;VALUE=DATE-TIME:20171109T120000Z
UID:https://talks.ox.ac.uk/talks/id/f5fff256-d02e-4a0e-8b38-033890d38d46/
DESCRIPTION:Advances in genomic technologies have enabled more rapid\, les
 s expensive genetic sequencing than was possible a few years ago. These te
 chnologies allow for the comprehensive genetic profiling for assessing ris
 ks to breast and ovarian cancers and include multiplex sequencing panels o
 f several genes and panels of common single nucleotide polymorphisms (SNPs
 ).  However\, the clinical utility of such multiplex gene and SNP panels d
 epends on having accurate estimates of cancer risks for mutations in the g
 enes included in such panels as well as cancer risk prediction models that
  consider the multifactorial aetiology to cancer susceptibility. Over the 
 past decade international consortia\, such as the Breast and Ovarian Cance
 r Association Consortia\, the Consortium of Investigators of Modifiers of 
 BRCA1/2 and the International BRCA1/2 Carrier Cohort Study have enabled us
  to accurately characterise the cancer risks for rare and common cancer su
 sceptibility genetic variants\; to understand how the genetic variants int
 eract with each other\; and how genetic variants interact with other lifes
 tyle/hormonal risk factors for the disease. The presentation will review t
 he key recent advances by these international consortia and how these are 
 helping us to realise a more personalised risk-based cancer prevention and
  cancer control. \nSpeakers:\nDr Antonis Antoniou (Centre for Cancer Genet
 ic Epidemiology\, Cambridge)
LOCATION:NDM Building (TDI\, Basement meeting room\, NDM Research Building
 )\, Headington OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f5fff256-d02e-4a0e-8b38-033890d38d46/
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DESCRIPTION:Talk:Breast and ovarian cancer susceptibility: what have we le
 arned from large international consortia? - Dr Antonis Antoniou (Centre fo
 r Cancer Genetic Epidemiology\, Cambridge)
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