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SUMMARY:Leveraging functional annotations to enhance trait prediction and 
 biological discovery - Dr Jian Zeng (University of Queensland)
DTSTART;VALUE=DATE-TIME:20250829T083000
DTEND;VALUE=DATE-TIME:20250829T100000
UID:https://talks.ox.ac.uk/talks/id/f94cbdf5-5860-4d30-a876-3db2ccf318e1/
DESCRIPTION:Join Zoom Meeting\nhttps://aarhusuniversity.zoom.us/j/65050948
 135\n\nMeeting ID: 650 5094 8135\n\n\nAbstract\nIntegrating phenotype and 
 genotype data with functional genomic annotations can deepen our understan
 ding of the genetic basis of complex traits. Previous studies have shown t
 hat the distribution of genetic effects varies across functional annotatio
 n categories\, partly shaped by natural selection. In this presentation\, 
 I will discuss statistical methods we have developed to leverage functiona
 l annotations for improving polygenic prediction of complex traits and for
  genome-wide fine-mapping of causal variants. I will also review current s
 trategies for integrating functional genomics with GWAS data to identify c
 ell types associated with complex traits\, share key lessons we learned fr
 om benchmarking different methods\, and present our findings from applying
  a temporal single-cell transcriptomic data analysis to psychiatric disord
 ers.\n\nBiography\nDr Jian Zeng is a Group Leader in statistical genetics 
 and an NHMRC Emerging Leadership Fellow at the Institute for Molecular Bio
 science (IMB) at the University of Queensland (UQ). He received his PhD in
  Quantitative Genetics from Iowa State University and joined the Program i
 n Complex Trait Genomics at UQ in 2016. His research focuses on developing
  and applying innovative statistical methods to understand the genetic arc
 hitecture of complex traits. He works on identifying genetic variants\, ge
 nes\, and molecular phenotypes associated with trait variation\, as well a
 s disease risk prediction using genome sequence data. Since 2022\, Dr Zeng
  has also served as Director of the Genetics & Genomics Winter School\, an
  annual in-person course held each July\, which provides training in compu
 tational methods for genetic data analysis. \n\nSpeakers:\nDr Jian Zeng (U
 niversity of Queensland)
LOCATION:Big Data Institute (LG0 Seminar Room)\, Old Road Campus OX3 7LF
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f94cbdf5-5860-4d30-a876-3db2ccf318e1/
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DESCRIPTION:Talk:Leveraging functional annotations to enhance trait predic
 tion and biological discovery - Dr Jian Zeng (University of Queensland)
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