Immune regulation of hyaluronan in the lung during challenge
In-person only.
A consistent feature of lung injury is a rapid and sustained accumulation of the extracellular matrix component hyaluronan (HA). Increased HA is found in the lungs after infection with SARS-CoV2 or influenza but also during asthma and allergy or exposure to pollutants. Here, I’ll present our recent work showing that the type-2 cytokine IL-13 is required for HA matrix formation in several models of lung challenge. Our aim now is to understand how IL-13 regulates these matrices and understand how HA accumulation and formation of specific HA matrices either contributes to effective tissue repair or drives lung pathology.
Date:
15 May 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Rebecca Dodd (University of Manchester)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Host:
Stephanie Dakin (NDORMS, University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Magdalena Gross
