Temporal regulation of genome replication

Conrad Nieduszynski’s group uses a variety of cellular, molecular, genomic, bio-informatic and modelling approaches to understand how DNA replication is regulated to ensure genome stability. By focusing on the basic biology that underpins cell growth and division, they aim to provide novel insights that will help our understanding of diseases such as cancer and congenital disorders. Their long-term research aims are to determine: i) how cells ensure that sufficient replication origins are activated to fully replicate the genome; ii) the mechanisms involved in faithfully completing genome replication; and, the physiological consequences of deregulated genome replication.