OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Mechanisms Generating Cell-Type Diversity in Cerebral Cortex
The concerted production of the correct number and diversity of neurons and glia is essential for intricate neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. We recently performed a quantitative clonal analysis by exploiting the unprecedented resolution of the genetic MADM (Mosaic Analysis with Double Markers) technology and discovered a high degree of non-stochasticity and thus deterministic mode of RGP behavior. However, the cellular and molecular mechanisms controlling the precise pre-programmed RGP lineage progression through proliferation, neurogenesis and gliogenesis remain unknown. To this end we use quantitative MADM-based experimental paradigms at single RGP resolution to define the non-cell-autonomous mechanisms and intrinsic functions of candidate genes controlling RGP-mediated cortical neuron and glia genesis and postnatal stem cell behavior.
For more information: zoltan.molnar@dpag.ox.ac.uk or noemi.picco@sjc.ox.ac.uk
Date:
25 June 2018, 16:00
Venue:
Le Gros Clark Building, off South Parks Road OX1 3QX
Venue Details:
Large Lecture Theatre
Speaker:
Simon Hippenmeyer, PhD (Institute of Science and Technology Austria)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Isabella Renehan (Department of Physiology Anatomy and Genetics)
Host:
Professor Zoltan Molnar (DPAG, University of Oxford)
Part of:
Neuroscience Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Isabella Renehan
