Can unbiased single-cell analysis of immune cells improve data-driven selection of tailored therapies in human atherosclerosis?

Atherosclerosis is a heterogenous disease characterized by immune infiltration of the arterial wall in response to tissue damage and systemic inflammation. Gaining a deeper knowledge of the immune contexture of atherosclerotic tissue, disease-specific molecular signatures and cell variation in patients is needed to design tailored therapies targeting the inflammatory dysfunction in these patients.