Seminar by Dr Gretchen Diehl "Developing microbiota directed immunity"
Immune responsiveness and antigen specific recognition of intestinal microbes must be tightly regulated. Unnecessary inflammation that can support conditions such as inflammatory bowel disease must be avoided while rapid responses to microbes that breach the epithelial barrier must be allowed. We are interested to understand this regulation and have identified an early life developmental window where intestinal microbes are trafficked to the thymus where naive T cells that recognize them are then expanded. These microbiota specific T cells can protect in infection models or induce pathology in models of inflammatory disease models. We are continuing to work to understand the peripheral role for these cells throughout life as well as the developmental changes into adulthood regulating these processes.
Date: 13 March 2023, 12:00 (Monday, 9th week, Hilary 2023)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held in the Kennedy Lecture Theatre with the option to join via Zoom at https://medsci.zoom.us/meeting/register/tJwuceCqqjwjGN1QUEDqwBrfRb_AuHEZYp4Q
Speaker: Dr Gretchen Diehl (Memorial Sloan Kettering Cancer Centre, New York)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: ellen.mobbs@kennedy.ox.ac.uk
Hosts: Elke Kurz (The Kennedy Institute of Rheumatology), Professor Mike Dustin (Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Roosevelt Drive, Oxford OX3 7FY)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJwuceCqqjwjGN1QUEDqwBrfRb_AuHEZYp4Q
Audience: Members of the University only
Editors: Ellen Mobbs, Lola Chaplin