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Phenome@BDI Seminar - Additional dimensions in mass spectrometry: velocity-map imaging
molecular fragments. In biological applications, mass spectrometry is used to characterise a wide variety of biomolecules, including sugars, proteins, and oligonucleotides; for example, sequencing of proteins and peptides and identification of post-translational modifications. While methods such as ion mobility spectrometry and H/D exchange techniques have been implemented in order to obtain additional structural information from mass spectra, none yield direct information on atomic connectivity within the structure. We have recently developed a new technique known as Coulomb-explosion covariance-map imaging, a variation on the velocity-map imaging method employed widely within the field of chemical reaction dynamics. While so far only applied to small molecules, our new approach provides direct structural information, and even promises the ability to follow structural change on the femtosecond timescale over which chemical change occurs.
Date:
28 October 2019, 15:00
Venue:
Big Data Institute (NDM), Old Road Campus OX3 7LF
Venue Details:
Seminar room 0
Speaker:
Professor Claire Vallance (Department of Chemistry)
Organising department:
Big Data Institute (NDM)
Part of:
BDI seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Graham Bagley
