Antisense transcription and epigenetic switching: lessons from FLC
How is gene expression quantitatively regulated? Through the study of how plants perceive and respond to winter, we have discovered that Arabidopsis FLC is an excellent system in which to mechanistically dissect how non-coding transcription and chromatin structure quantitatively regulate gene expression. In the warm, an antisense-mediated chromatin mechanism coordinately influences transcriptional initiation and elongation. With increasing cold exposure, FLC is epigenetically silenced through a conserved Polycomb switching mechanism. The talk will describe our latest understanding of this regulation and how it has been modulated during adaptation.
Date: 23 October 2017, 13:00 (Monday, 3rd week, Michaelmas 2017)
Venue: Biochemistry Building, off South Parks Road OX1 3QU
Venue Details: Main Seminar Room
Speaker: Professor Dame Caroline Dean (Project Leader, John Innes Centre, Norwich)
Organising department: Department of Biochemistry
Organiser: Sarah-jane Scard (Department of Biochemistry)
Organiser contact email address: head@bioch.ox.ac.uk
Host: Professor Jane Mellor (Department of Biochemistry, University of Oxford)
Part of: Biochemistry Department Seminar
Booking required?: Not required
Audience: Members of the University only
Editor: Sarah-Jane Scard