DNA methylation in mammals: a DNA methyltransferase can hide another
Déborah Bourc’his’ team is focused on understanding the nature and the role of the epigenetic information in gametogenesis, fertilization and early embryonic development. Her work is mostly centered on DNA methylation, how it influences gametic production and integrity, and impacts on phenotypes at following generations. Studying the epigenetic setting of germ cells allows investigation of several crucial aspects of mammalian biology such as transposon control, genomic imprinting and early lineage commitment. Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio-temporal control of genomic methylation specificity, including components of histone modification and RNA-directed pathways. Her work uses fine developmental and molecular dissection, combined with genetic tools (CRISPR) and genome-wide sequencing approaches.
Date: 20 April 2017, 11:00 (Thursday, 0th week, Trinity 2017)
Venue: NDM Building, Headington OX3 7FZ
Venue Details: TDI, Basement Seminar Room
Speaker: Dr. Déborah Bourc'his (Institut Curie, Paris)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organiser: Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address: mary.muers@ludwig.ox.ac.uk
Host: Dr Skirmantas Kriaucionis (Ludwig Cancer Research)
Part of: Ludwig Institute Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Mary Muers