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The evolutionary dynamics of antibiotic resistance: insights from experimental evolution with pseudomonas
Antibiotic resistance in pathogenic bacteria is a simple and elegant example of adaptation by natural selection. In my talk, I will show how simple experiments can be used to investigate the fundamental evolutionary processes that drive the spread and maintenance of antibiotic resistance in Pseudomonas. Antibiotic resistance comes at a fitness cost, expressed in terms of reduced competitive ability and virulence, and I will focus on addressing two issues. First, why does resistance carry a cost? Second, how do antibiotic use and natural selection allow resistance to persist over the long term in spite of its initial cost?
Date:
17 March 2015, 13:00
Venue:
Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details:
EPA Seminar Room
Speaker:
Craig Maclean (Department of Zoology)
Part of:
Bug Sessions in infectious disease
Booking required?:
Not required
Audience:
Members of the University only
