OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
There is an urgent need to identify non-demented individuals at the highest risk of progressing to Alzheimer’s dementia. In this talk, I will introduce the polygenic hazard score (PHS) derived using a survival analysis framework for predicting Alzheimer’s dementia age of onset. I will then present findings showing that PHS is associated with neuroimaging biomarkers, cognitive decline, and clinical progression. The potential utility of PHS in the clinic and for clinical trials will also be discussed.
