A hundred years on: 21st Century Insights into Human Oxygen Homeostasis
Please note the lecture theatre capacity is restricted to 190 and seating is first come first served (Oxford University members only).
In 1911, work by Haldane, Fitzgerald and colleagues revealed the extraordinary sensitivity of blood haemoglobin levels to reduced atmospheric oxygen levels, a finding that introduced the physiological concept of an oxygen sensor. This lecture will outline advances in the molecular understanding of oxygen sensing mechanisms, including the remarkable finding that all eukaryotic kingdoms use enzymatic protein oxidations coupled to proteostasis to signal oxygen levels in their cells. The physiological implications of these advances will be discussed, together with the opportunities and challenges raised in the therapeutic modulation of human oxygen sensing systems.
Date: 21 November 2019, 16:00 (Thursday, 6th week, Michaelmas 2019)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Large Lecture Theatre
Speaker: Peter J Ratcliffe (Professor of Medicine, University of Oxford and Director of Clinical Research, Francis Crick Institute, London)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor David Paterson (University of Oxford)
Organiser contact email address: hod-pa@dpag.ox.ac.uk
Host: Professor David Paterson (University of Oxford)
Part of: The John Scott Haldane Prize Lecture
Topics:
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith