Realizing The Promise of Cardiac Neuromodulation: Clinical & Laboratory Insights Paving the Path
The autonomic nervous system is central to homeostatic regulation of the heart across physiological states. In the setting of chronic cardiac injury, initially protective adaptive mechanisms orchestrated by the autonomic nervous system become deleterious. Structural and functional remodelling of neuronal and non-neuronal elements comprising reflex heart-brain circuits promote maladaptive processes that worsen cardiac function and enhance arrhythmias. Employing approaches ranging from in silico to mechanistic clinical studies, our work elucidates mechanisms governing adverse neural remodelling and develops interventions targeting nexus points within heart-brain reflex circuits to treat chronic heart disease.
Date:
16 October 2023, 16:00 (Monday, 2nd week, Michaelmas 2023)
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Blakemore Lecture Theatre
Speaker:
Associate Professor Olujimi Ajijola (Associate Professor of Medicine, UCLA-Cardiac Arrhythmia Center & EP Programs, Co-Director UCLA-Caltech MST)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor David Paterson (DPAG, University of Oxford)
Organiser contact email address:
hod-pa@dpag.ox.ac.uk
Host:
Professor David Paterson (DPAG, University of Oxford)
Part of:
Burdon Sanderson Prize Lecture
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Talitha Smith
