OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The availability of very large open access human phenotype, electronic medical record and genotype resources is changing the way we can do research. Instead of focusing on a particular problem and gathering data to address that problem, we can now ask “what problems can we address given we have 1000s of datapoints in 100,000s of people?”
I will present some examples of our recent use of UK Biobank and other big human genetic resources to test hypotheses about genetic variation and mechanisms of disease, with a particular focus on obesity, body fat distribution and related traits. These examples include i) the characterisation of “favourable adiposity” alleles and their potential use to “uncouple” higher body fat from its adverse metabolic consequences; ii) advancing our understanding of gene x lifestyle interactions that are features of obesity, and iii) characterisation of the phenotypes associated with genetic variation, unbiased by any clinical selection, including X chromosome aneuploidy.
