Brain vulnerability for psychosis: from mechanisms to real-world outcomes
New approaches that bridge knowledge across genes and proteins to cells to whole-brain networks and to behaviour are beginning to transform our understanding of how the brain works in health and disease.
Translation of neuroimaging results depend on this mechanistic understanding and is critical for discovery of new druggable targets. This talk will provide an overview of recent work using our lab combining multimodal brain imaging methods to ask questions about the interactions between neurochemistry, neurophysiology and neuroanatomy in psychosis vulnerability, with a ficus on brain excitation-inhibition balance.
I will discuss our recent research using preclinical models and bioinformatic approaches to delineate with increased precision the biological mechanisms involved in the human neuroimaging observations. We also apply experimental medicine approaches to probe how to intervene on those mechanisms early to prevent or delay the development of psychosis.
Finally, and in parallel, we work to integrate this mechanistic understanding with large-scale approaches to neuroimaging data (ENIGMA Schizotypy) and real-world clinical outcomes using electronic health records.
Date:
8 October 2024, 11:00 (Tuesday, 0th week, Michaelmas 2024)
Venue:
Department of Psychiatry, Headington OX3 7JX
Venue Details:
Seminar Room
Speaker:
Dr Gemma Modinos (Kings College London)
Organising department:
Department of Psychiatry
Organiser:
Rania Elgarf (Department of Psychiatry, University of Oxford)
Organiser contact email address:
rania.elgarf@psych.ox.ac.uk
Host:
Philip McGuire (Professor of Psychiatry, University of Oxford. Academic Director, SPRINT. Principal Investigator, Wellcome Centre for Integrative Neuroimaging)
Part of:
Psychiatry Seminar Series
Booking required?:
Not required
Audience:
Public
Editor:
Rania Elgarf
