*CANCELLED* Tracking Jak-STAT signalling in inflammatory arthritis
Status: This talk is in preparation - details may change
Status: This talk has been cancelled
This event is now cancelled. Apologies for any inconveniences caused.
Immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA) are highly context dependent. Rheumatoid arthritis patients often display very different patterns of local synovial pathology– termed fibroblast-rich, myeloid-rich and lymphoid-rich synovitis. My overarching goal is to identify the decision-making processes affecting the clinical presentation of these synovial pathotypes. Combining functional genomic approaches and histological studies in mice and humans I will discuss how cells within the inflamed synovium sense and interpret cytokine cues linked with these pathotypes. With a primary focus on cytokines that signal through the latent transcription factors STAT1 and STAT3, I will provide new insights into the potential role of protein tyrosine phosphatases as biological rheostats of Jak-STAT signalling within the inflamed joint.
Date: 23 March 2020, 12:00 (Monday, 10th week, Hilary 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Professor Simon Jones (Cardiff University)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Public
Editor: Jennifer Pope