Finally: empty class I molecules
Empty MHC class I molecules are known to exist, but they are difficult to investigate. I will explain what we have learnt – using a novel antibody micropatterning two-hybrid assay – about the ability of free heavy chains to form in cis clusters on the cell surface. In the second part, I will focus on our recent development of stable recombinant class I molecules . They can be used to make empty tetramers that load within seconds with any added peptide, with interesting applications in tumor epitope screening.
Date: 1 October 2018, 13:30 (Monday, 0th week, Michaelmas 2018)
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: WIMM Seminar Room
Speaker: Prof Sebastian Springer (Jacobs University Bremen, Germany)
Organising department: MRC Human Immunology Unit
Organiser: Anne Farmer
Organiser contact email address:
Host: Professor Alain Townsend (University of Oxford)
Part of: MRC TIDU Wednesday Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Renata Sojka