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Finally: empty class I molecules
Empty MHC class I molecules are known to exist, but they are difficult to investigate. I will explain what we have learnt – using a novel antibody micropatterning two-hybrid assay – about the ability of free heavy chains to form in cis clusters on the cell surface. In the second part, I will focus on our recent development of stable recombinant class I molecules . They can be used to make empty tetramers that load within seconds with any added peptide, with interesting applications in tumor epitope screening.
Date:
1 October 2018, 13:30
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar Room
Speaker:
Prof Sebastian Springer (Jacobs University Bremen, Germany)
Organising department:
MRC Human Immunology Unit
Organiser:
Anne Farmer
Organiser contact email address:
anne.farmer@imm.ox.ac.uk
Host:
Professor Alain Townsend (University of Oxford)
Part of:
MRC TIDU Wednesday Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Renata Sojka
