OxTalks is Changing
OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected in early Hilary to allow all events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed as soon as possible.
If you have any questions, please contact halo@digital.ox.ac.uk
Multi-omics approaches to understand immune cell biology in health and disease
B cells and T cells are important components of the adaptive immune system and mediate anti-cancer immunity. In this talk, I will present two recent studies that harness multi-omics technologies to unveil groundbreaking insights into immune cell immunosurveillance across metastatic sites and patient-specific responses to tumours. Our research reveals a dynamic co-evolution between B and T cell immune responses and metastatic cancer genomes, with B cell clones demonstrating remarkable predictability in immunosurveillance—a finding with broad relevance across immune-mediated diseases. Using single-cell multi-omics in pancreatic cancer, we identify two distinct immune microenvironments and their driving mechanisms: myeloid-enriched (linked to poor prognosis) and adaptive-enriched (associated with robust B/T cell clonal expansion and better outcomes). This work offers a novel blueprint for prioritising antibody sequences for therapeutic development and guiding rational combination immunotherapies, paving the way for more effective, personalised cancer treatments.
Date:
7 May 2025, 16:00
Venue:
Venue to be announced
Speaker:
Prof Rachael Bashford-Rogers (Department of Biochemistry, University of Oxford)
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser:
Dr Eoghan Mulholland (University of Oxford)
Organiser contact email address:
eoghan.mulholland@well.ox.ac.uk
Host:
Dr Eoghan Mulholland (University of Oxford)
Part of:
GO-PRECiSE Seminar Series (GPS)
Booking required?:
Recommended
Booking url:
https://forms.office.com/e/23z5aHNExj
Audience:
Public
Editor:
Eoghan Mulholland
