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Multi-omics approaches to understand immune cell biology in health and disease
B cells and T cells are important components of the adaptive immune system and mediate anti-cancer immunity. In this talk, I will present two recent studies that harness multi-omics technologies to unveil groundbreaking insights into immune cell immunosurveillance across metastatic sites and patient-specific responses to tumours. Our research reveals a dynamic co-evolution between B and T cell immune responses and metastatic cancer genomes, with B cell clones demonstrating remarkable predictability in immunosurveillance—a finding with broad relevance across immune-mediated diseases. Using single-cell multi-omics in pancreatic cancer, we identify two distinct immune microenvironments and their driving mechanisms: myeloid-enriched (linked to poor prognosis) and adaptive-enriched (associated with robust B/T cell clonal expansion and better outcomes). This work offers a novel blueprint for prioritising antibody sequences for therapeutic development and guiding rational combination immunotherapies, paving the way for more effective, personalised cancer treatments.
Date:
7 May 2025, 16:00
Venue:
Venue to be announced
Speaker:
Prof Rachael Bashford-Rogers (Department of Biochemistry, University of Oxford)
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser:
Dr Eoghan Mulholland (University of Oxford)
Organiser contact email address:
eoghan.mulholland@well.ox.ac.uk
Host:
Dr Eoghan Mulholland (University of Oxford)
Part of:
GO-PRECiSE Seminar Series (GPS)
Booking required?:
Recommended
Booking url:
https://forms.office.com/e/23z5aHNExj
Audience:
Public
Editor:
Eoghan Mulholland
