Signalosomes – Nodal Regulators and Therapeutic Targets For Heart Failure
Specificity and efficacy in intracellular signal transduction can be conferred by the anchoring and co-localization of key enzymes and their upstream activators and substrate effectors by scaffold proteins. The Kapiloff lab studies how signalosomes organized by scaffold proteins regulate cellular function in the heart and eye, in particular regarding pathological cardiac myocyte hypertrophy and retinal ganglion cell neuroprotection. A major focus of our laboratory has been the characterization of multimolecular signaling complexes organized by the scaffold protein mAKAPβ located at the nuclear envelope in cardiac myocytes. Our research into the mechanisms of mAKAPβ signalosome function has evolved now into the preclinical development of mAKAPβ-targeted gene therapy for the prevention of heart failure. Separately, research has revealed a new mechanism for calcineurin Aβ-specific anchoring that confers compartmentation specific for the regulation of cardiac hypertrophy.
Date: 18 September 2019, 16:00 (Wednesday, 21st week, Trinity 2019)
Venue: Sherrington Library, off Parks Road OX1 3PT
Speaker: Dr Michael Kapiloff (Associate Professor, Departments of Ophthalmology and Medicine (Division of Cardiovascular Medicine), Stanford University, Palo Alto, CA)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Organiser contact email address: manuela.zaccolo@balliol.ox.ac.uk
Host: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Part of: Cardiac Sciences Theme Guest Speakers
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith