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Mast cells help organize the Peyer’s patch niche for induction of IgA responses
No virtual option for this seminar
Peyer’s patches (PPs) support the production of intestinal IgA. Induction of IgA+ cells in PPs requires interactions between B cells and conventional dendritic cells type 2 (cDC2s) in the subepithelial dome (SED). We found that cDC2s express GPR35, a receptor that promotes migration to 5-hydroxyindoleacetic acid (5-HIAA). In mice lacking GPR35, there was a loss of cDC2s from the SED and of IgA+ cells. Mast cells were present in the SED and ablation of 5-HIAA production in mast cells phenocopied the absence of GPR35. Thus, mast cell-guided positioning of GPR35+ cDC2s in the SED supports induction of intestinal IgA responses.
Date:
19 February 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Lecture Theatre
Speaker:
Dr. Marco De Giovanni (Vita-Salute San Raffaele University (Milan, Italy))
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
