OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Early Neuronal Diversity Shapes Cortical Circuit Assembly
Neural circuit assembly relies on the precise synchronisation of developmental processes such as cell migration and axon targeting, but the cell autonomous mechanisms coordinating these events remain largely unknown. We found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive class of cortical interneurons. For these cells, migration through the marginal zone is linked to the development of their characteristic layer 1 axonal arborization. Alteration of the normal migratory route of Martinotti cells by conditional deletion of Mafb – a gene that is preferentially expressed by these cells – cell-autonomously disrupts axonal development and impairs the function of these cells in vivo. Our results suggest that migration and axon targeting programs are coupled to optimize the assembly of inhibitory circuits in the cerebral cortex.
Date:
26 June 2018, 11:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Library
Speaker:
Dr Lynette Lim (MCR Centre for Developmental Neurobiology, King's College London)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Host:
Professor Andrew King (University of Oxford)
Part of:
Neuroscience Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Isabella Renehan
