Developmental programmes in cancer
Developmental programs can be co-opted to drive cancer progression. Embryos are born with a set of genetic blueprints encoded in their DNA, yet during development, cells diversify to take on new fates above and beyond their genomes. This diversification is enacted in part by transcriptional/epigenetic programs as well as cell-cell interactions. Similarly, tumor cells utilize many of these same developmental programs but do so in the face of a highly disordered genome. Understanding how the cancer genome interacts with these developmental programs is central to determining which cells are capable of tumor initiation and how they metastasize. I will discuss our recent findings on how these developmental principles can be used to understand cancer initiation and progression.
Date: 25 January 2023, 15:00 (Wednesday, 2nd week, Hilary 2023)
Venue: IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details: Seminar Room 1&2
Speaker: Professor Richard White (Oxford Ludwig Institute)
Host: Dr Filipa Simões (DPAG, IDRM, University of Oxford)
Part of: IDRM Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Rufina Kaloyanova