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Spatial Proteomics Relates Metabolic T Cell Flexibility to Successful Cancer Immunotherapy
In person only
T cell metabolism shapes immune function, but how CD8+ T cell flexibility relates to immunotherapy response is unclear. Using spatial proteomics, we map a metabolic continuum of tumor-infiltrating CD8+ T cells defined by differential fermentative and oxidative engagement. These states display distinct immune interactomes and metabolic niches, reflecting lineage-transcending regulator patterns. Metabolic flexibility, such as lactate utilization, characterized responder tumors and correlated with enriched memory and progenitor-exhausted signatures in transcriptomic datasets. Machine learning integration of metabolic and immunological profiles predicted checkpoint blockade response. Our findings position metabolic flexibility, not abundance, as central to durable antitumor immunity.
Date:
27 October 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Felix Hartmann (German Cancer Research Center)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Host:
Professor Christopher Buckley (Kennedy Institute of Rheumatology, University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Booking url:
https://go.brukerspatialbiology.com/OxfordCoffeeandlearn.html
Audience:
Members of the University only
Editor:
Magdalena Gross
