Dr Duncan Sparrow : Environmental influences on mouse heart development
Congenital heart disease (CHD) is the most common type of human birth defect with an incidence of ~1% of live births. However, despite the rapid advances in research into the genetic causes of rare diseases brought about by next-generation sequencing technologies, still only about 20% of CHD cases have been shown to have a simple genetic cause. This suggests that many CHD cases have multifactorial causes. One of these factors is likely to be environmental. Although embryonic development is primarily controlled genetically, it has long been known that perturbation of the environment in which the embryo forms can have a dramatic effect. For example, fetal under- or over-nutrition can have long-lasting metabolic or epigenetic effects, manifesting in altered physiology in adult life. By contrast, I have shown that one particular environmental insult, short-term exposure of mouse embryos in utero to hypoxia, can have a transient effect and results in a variety of specific gross morphological abnormalities including heart and vertebral defects. The majority of the heart defects induced in this way are conotruncal in nature, and arise as a result of interrupted development of the outflow tract and its precursor tissue, the second heart field. This effect is mediated at the molecular level by an interruption of FGF signalling, and the penetrance and severity of both heart and vertebral defects can be further exacerbated by genetic risk factors. FGF signalling has key roles in many other processes during embryogenesis, including brain, kidney, limb and craniofacial development. This raises the possibility that interactions between an environmentally-induced reduction of FGF signalling, coupled with a genetic deficit, may play an important role in the etiology of a wide range of “sporadic” human congenital defects.
Date: 13 May 2016, 13:00 (Friday, 3rd week, Trinity 2016)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: DPAG Large Lecture Theatre, Sherrington Building, off Parks/South Parks Road, OX1 3PT T: 01865 272500
Speaker: Associate Professor Duncan Sparrow (DPAG, University of Oxford)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Sarah Noujaim (University of Oxford, Department of Physiology Anatomy and Genetics)
Organiser contact email address: sarah.noujaim@dpag.ox.ac.uk
Part of: DPAG Head of Department Seminar Series
Topics:
Booking required?: Not required
Audience: Members of the University only
Editor: Sarah Noujaim