Metabolic regulation of T cell signalling and function
No virtual option for this seminar
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. We found that two separate phosphoinositde (PIPn) pools, marked by different acyl chain compositions, drive important signalling events at specific stages of Teff cell differentiation. Teff cell PIPn signaling was maintained by the rapid and continuous de novo saturated PI synthesis from glucose, directly tying the nutrient environment with Teff signaling. Saturated PI synthesis was increased in CD8+ TILs, and CDIPT, which catalyses the final enzymatic step in de novo PI synthesis, was required for CD8+ TIL antitumor fitness and function. T cells with improved antitumor function following checkpoint inhibitor therapy synthesized more saturated PIPn in mouse and human melanoma.
Date: 20 November 2023, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Dr Joy Edwards-Hicks (University of Cambridge)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address: doris.chan@kennedy.ox.ac.uk
Host: Alexander Clarke (Kennedy Institute, University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan