On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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The locus coeruleus (LC), the brain’s principal noradrenergic nucleus, is among the first regions to show tau pathology in Alzheimer’s disease (AD). Its widespread projections regulate arousal, attention, sleep–wake dynamics, often disrupted early in the disease. This seminar will explore recent evidence on the degeneration of the LC across the Alzheimer’s disease continuum, integrating post-mortem, neuroimaging, and cerebrospinal fluid biomarker data. I will discuss how LC dysfunction contributes to cognitive, neuropsychiatric, and sleep alterations in AD, and how targeting this system may open novel diagnostic and therapeutic avenues.
