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Locus coeruleus degeneration in Alzheimer’s disease
Join us in person or remotely via Teams - e-mail carolyn.thackrah@pharm.ox.ac.uk for joining instructions
The locus coeruleus (LC), the brain’s principal noradrenergic nucleus, is among the first regions to show tau pathology in Alzheimer’s disease (AD). Its widespread projections regulate arousal, attention, sleep–wake dynamics, often disrupted early in the disease. This seminar will explore recent evidence on the degeneration of the LC across the Alzheimer’s disease continuum, integrating post-mortem, neuroimaging, and cerebrospinal fluid biomarker data. I will discuss how LC dysfunction contributes to cognitive, neuropsychiatric, and sleep alterations in AD, and how targeting this system may open novel diagnostic and therapeutic avenues.
Date:
4 November 2025, 12:00
Venue:
Pharmacology, off Mansfield Road OX1 3QT
Venue Details:
David Smith Lecture Theatre
Speaker:
Dr Neus Falgas (Neurology Department, Hospital Clínic de Barcelona)
Organising department:
Department of Pharmacology
Organiser:
Carolyn Thackrah (University of Oxford, Department of Pharmacology)
Organiser contact email address:
carolyn.thackrah@pharm.ox.ac.uk
Part of:
Pharmacology, Anatomical Neuropharmacology and Drug Discovery Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Carolyn Thackrah
