Guest Spkr Prof Ester Hammond - ‘Hypoxia induced replication stress: causes, consequences and opportunities’
Regions of low oxygen (hypoxia) occur in most solid tumours and correlate with poor patient prognosis. Importantly, hypoxia also leads to resistance to radiotherapy. Previous work from my lab has described the DNA damage response which is initiated in response to hypoxia-induced replication stress. The cause and consequence of this replication stress is the subject of on-going work in the lab. Currently, we are focused on the ribonucleotide reductase (RNR) enzyme, which is an oxygen-dependent enzyme that is responsible for the de novo conversion of NDPs to dNDPs – the building blocks of DNA synthesis. One of the small subunits of RNR (RRM2B) has been shown previously to be induced after DNA damage and specifically after irradiation. The purpose of our study was to investigate if RRM2B has a role for maintaining replication in hypoxic conditions (<0.1% O2), these data will be discussed.
Date: 14 October 2016, 13:00 (Friday, 1st week, Michaelmas 2016)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: DPAG, Large Lecture Theatre, Sherrington Building, off South Parks and Parks Road, Oxford OX1 3PT - 01865 272500
Speaker: Professor Ester Hammond (Gray Institute for Radiation, Oncology and Biology, University of Oxford)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Sarah Noujaim (University of Oxford, Department of Physiology Anatomy and Genetics)
Organiser contact email address: deborah.goberdhan@dpag.ox.ac.uk
Host: Professor Deborah Goberdhan (DPAG , University of Oxford)
Part of: DPAG Head of Department Seminar Series
Topics: Radiation
Booking required?: Not required
Audience: Members of the University only
Editor: Sarah Noujaim