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Non-coding RNAs in immunity and inflammation
I will discuss novel mechanistic links between long and short non-coding RNAs (ncRNAs) and mammalian immune responses in the context of chronic inflammation with a particular focus on CD4+ T cell responses and gene regulation in the endothelium. Data from human primary cells and whole animal models of deficiency of highly conserved miRNAs or lncRNAs will be presented. The overarching implication of this work is that ncRNAs are non-redundant regulators of immunity and that studying ncRNAs can provide critical insights into unique features of the mammalian immune system.
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Dimitris Lagos is a Senior Lecturer in Immunology at the University of York. After completing his training as a chemical engineer in Athens he moved to Sheffield to pursue a PhD in monoclonal antibody engineering, spending time in AstraZeneca and the University of Zurich. Following his PhD, he moved to the CRUK Viral Oncology Group at UCL to study host responses to oncogenic viruses. There he developed a strong interest in immune gene expression regulation and specifically non-coding RNAs, which remains the focus of his group. His work has been supported by the MRC (including New Investigator, Global Challenges Research Fund, and Confidence in Concept research grants), The Wellcome Trust, and the BBSRC.
Date:
19 February 2018, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Dimitris Lagos (University of York)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Laura Sánchez Lazo (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology),
Jo Silva (NDORMS),
Wulf Forrester-Barker (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences)
Host:
Prof Mark Coles (SENIOR RESEARCH FELLOW AND NEW GROUP LEADER)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Laura Sanchez Lazo
